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DC Field | Value | Language |
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dc.contributor.author | Katulanda, G.W. | - |
dc.contributor.author | Katulanda, P. | - |
dc.contributor.author | Adler, A.I. | - |
dc.contributor.author | Peris, S.R. | - |
dc.contributor.author | Draisey, I. | - |
dc.contributor.author | Wijeratne, S. | - |
dc.contributor.author | Sheriff, M.H.R. | - |
dc.contributor.author | Matthews, D.R. | - |
dc.contributor.author | Shine, Brian | - |
dc.date.accessioned | 2021-11-03T06:09:41Z | - |
dc.date.available | 2021-11-03T06:09:41Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Katulanda, G. W., Katulanda, P., Adler, A. I., Peiris, S. R., Draisey, I., Wijeratne, S., ... & Shine, B. (2010). Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns. Annals of clinical biochemistry, 47(1), 29-34. | en_US |
dc.identifier.uri | http://archive.cmb.ac.lk:8080/xmlui/handle/70130/6264 | - |
dc.description | Annals of clinical Biochemistry: 2010; 47; 29-34p. | en_US |
dc.description.abstract | Background: Apolipoproteins B (apoB) and AI (apoAI) are strong predictors of cardiovascular disease (CVD). We describe apolipoprotein distributions and their associations with lipids and diabetes subtype in diabetic young adult South Asians. Methods: In 995 subjects with diabetes, we measured fasting total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), triglycerides (TG), apoB and apoAI, glycosylated haemoglobin (HbA1c) and glutamic acid decarboxylase antibodies (GADA). Low-density lipoprotein cholesterol (LDLC) and non-HDLC (NHDLC) were calculated. We compared values in subjects aged 15-50 y from the United States National Health and Nutrition Examination Survey (NHANES). Results: Median age and duration of diabetes were 38 (range 14-45) and 4 (0-24) y. Men had significantly higher TC, TG, NHDLC, TC/HDLC, apoB/AI and NHDLC/apoB, and lower apoAI than women. Compared with the reference group, patients with type 1 diabetes had lower TG, apoB:apoAI and HDLC:apoAI, and higher HDLC and apoAI. Patients with type 2 diabetes had higher TG, TC, LDLC, NHDLC, TC:HDL, apoB, apoAI and apoB:apoAI, and lower HDLC, LDLC:apoB and HDLC:apoAI. Among patients with type 2 diabetes, 54% had high apoB (>1.2 g/L) and 33% also had high TG (>1.5 mmol/L). Measures of obesity (body mass index and waist circumference) were weakly correlated with lipid and apoprotein parameters, suggesting a modest contribution to dyslipidaemia. Conclusions: A large proportion of young adult Sri Lankan patients with type 2 diabetes has a low LDLC:apoB and high apoB and/or TG, suggesting that these patients are at increased risk of CVD. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Sage Journals | en_US |
dc.title | Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns | en_US |
dc.type | Article | en_US |
Appears in Collections: | Articles (local / International) |
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File | Description | Size | Format | |
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Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult.pdf | 175.11 kB | Adobe PDF | View/Open |
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