Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/6264
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dc.contributor.authorKatulanda, G.W.-
dc.contributor.authorKatulanda, P.-
dc.contributor.authorAdler, A.I.-
dc.contributor.authorPeris, S.R.-
dc.contributor.authorDraisey, I.-
dc.contributor.authorWijeratne, S.-
dc.contributor.authorSheriff, M.H.R.-
dc.contributor.authorMatthews, D.R.-
dc.contributor.authorShine, Brian-
dc.date.accessioned2021-11-03T06:09:41Z-
dc.date.available2021-11-03T06:09:41Z-
dc.date.issued2010-
dc.identifier.citationKatulanda, G. W., Katulanda, P., Adler, A. I., Peiris, S. R., Draisey, I., Wijeratne, S., ... & Shine, B. (2010). Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns. Annals of clinical biochemistry, 47(1), 29-34.en_US
dc.identifier.urihttp://archive.cmb.ac.lk:8080/xmlui/handle/70130/6264-
dc.descriptionAnnals of clinical Biochemistry: 2010; 47; 29-34p.en_US
dc.description.abstractBackground: Apolipoproteins B (apoB) and AI (apoAI) are strong predictors of cardiovascular disease (CVD). We describe apolipoprotein distributions and their associations with lipids and diabetes subtype in diabetic young adult South Asians. Methods: In 995 subjects with diabetes, we measured fasting total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), triglycerides (TG), apoB and apoAI, glycosylated haemoglobin (HbA1c) and glutamic acid decarboxylase antibodies (GADA). Low-density lipoprotein cholesterol (LDLC) and non-HDLC (NHDLC) were calculated. We compared values in subjects aged 15-50 y from the United States National Health and Nutrition Examination Survey (NHANES). Results: Median age and duration of diabetes were 38 (range 14-45) and 4 (0-24) y. Men had significantly higher TC, TG, NHDLC, TC/HDLC, apoB/AI and NHDLC/apoB, and lower apoAI than women. Compared with the reference group, patients with type 1 diabetes had lower TG, apoB:apoAI and HDLC:apoAI, and higher HDLC and apoAI. Patients with type 2 diabetes had higher TG, TC, LDLC, NHDLC, TC:HDL, apoB, apoAI and apoB:apoAI, and lower HDLC, LDLC:apoB and HDLC:apoAI. Among patients with type 2 diabetes, 54% had high apoB (>1.2 g/L) and 33% also had high TG (>1.5 mmol/L). Measures of obesity (body mass index and waist circumference) were weakly correlated with lipid and apoprotein parameters, suggesting a modest contribution to dyslipidaemia. Conclusions: A large proportion of young adult Sri Lankan patients with type 2 diabetes has a low LDLC:apoB and high apoB and/or TG, suggesting that these patients are at increased risk of CVD.en_US
dc.language.isoenen_US
dc.publisherSage Journalsen_US
dc.titleApolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patternsen_US
dc.typeArticleen_US
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