Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/6043
Title: Profound thrombocytopenia and generalized hyperpigmentation following pyrimethamine use
Authors: Senanayake, M. P.
Mettananda, D. S. G.
Vidyatilake, Sudharma
Keywords: Pyrimethamine
profound thrombocytopenia
hyperpigmentation
Issue Date: 2011
Publisher: Sri Lanka college of pediatricians
Citation: Senanayake, M. P., Mettananda, D. S. G., & Vidyatilake, S. (2011). Profound thrombocytopenia and generalized hyperpigmentation following pyrimethamine use. Sri Lanka Journal of Child Health, 40, 134-135.
Abstract: Pyrimethamine is an effective anti-parasitic medication with a narrow therapeutic index. We report a child with toxoplasmosis who developed hyperpigmentation and profound thrombocytopenia during a course of treatment with pyrimethamine. These two unusual complications occurred in addition to folate deficiency and megaloblastic anaemia which are recognized adverse effects of this medication.
Pyrimethamine is an effective anti-parasitic medication with a narrow therapeutic index. We report a child with toxoplasmosis who developed hyperpigmentation and profound thrombocytopenia during a course of treatment with pyrimethamine. These two unusual complications occurred in addition to folate deficiency and megaloblastic anaemia which are recognized adverse effects of this medication
URI: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/6043
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