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DC Field | Value | Language |
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dc.contributor.author | Eddleston, Michael | |
dc.contributor.author | Juszczak, Edmund | |
dc.contributor.author | Buckley, Nick A. | |
dc.contributor.author | Senarathna, Lalith | |
dc.contributor.author | Mohamed, Fahim | |
dc.contributor.author | Dissanayake, Wasantha | |
dc.contributor.author | Hittarage, Ariyasena | |
dc.contributor.author | Azher, Shifa | |
dc.contributor.author | Jeganathan, K. | |
dc.contributor.author | Jayamanne, Shaluka | |
dc.date.accessioned | 2021-09-02T07:25:40Z | |
dc.date.available | 2021-09-02T07:25:40Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Eddleston, M., Juszczak, E., Buckley, N. A., Senarathna, L., Mohamed, F., Dissanayake, W., ... & Ox-Col Poisoning Study collaborators. (2008). Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial. The Lancet, 371(9612), 579-587. | en_US |
dc.identifier.uri | http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5860 | - |
dc.description.abstract | The case-fatality for intentional self-poisoning in the rural developing world is 10-50-fold higher than that in industrialised countries, mostly because of the use of highly toxic pesticides and plants. We therefore aimed to assess whether routine treatment with multiple-dose activated charcoal, to interrupt enterovascular or enterohepatic circulations, offers benefit compared with no charcoal in such an environment. We did an open-label, parallel group, randomised, controlled trial of six 50 g doses of activated charcoal at 4-h intervals versus no charcoal versus one 50 g dose of activated charcoal in three Sri Lankan hospitals. 4632 patients were randomised to receive no charcoal (n=1554), one dose of charcoal (n=1545), or six doses of charcoal (n=1533); outcomes were available for 4629 patients. 2338 (51%) individuals had ingested pesticides, whereas 1647 (36%) had ingested yellow oleander (Thevetia peruviana) seeds. Mortality was the primary outcome measure. Analysis was by intention to treat. The trial is registered with controlled-trials.com as ISRCTN02920054.Mortality did not differ between the groups. 97 (6.3%) of 1531 participants in the multipledose group died, compared with 105 (6.8%) of 1554 in the no charcoal group (adjusted odds ratio 0.96, 95% CI 0.70-1.33). No differences were noted for patients who took particular poisons, were severely ill on admission, or who presented early. We cannot recommend the routine use of multiple-dose activated charcoal in rural Asia Pacific; although further studies of early charcoal administration might be useful, effective affordable treatments are urgently needed. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.title | Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial | en_US |
dc.type | Article | en_US |
Appears in Collections: | Articles (local / International) |
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File | Description | Size | Format | |
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Multiple-dose activated charcoal in acute self poisoning a randomised controlled trial.pdf | 253.75 kB | Adobe PDF | View/Open |
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