Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5860
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dc.contributor.authorEddleston, Michael
dc.contributor.authorJuszczak, Edmund
dc.contributor.authorBuckley, Nick A.
dc.contributor.authorSenarathna, Lalith
dc.contributor.authorMohamed, Fahim
dc.contributor.authorDissanayake, Wasantha
dc.contributor.authorHittarage, Ariyasena
dc.contributor.authorAzher, Shifa
dc.contributor.authorJeganathan, K.
dc.contributor.authorJayamanne, Shaluka
dc.date.accessioned2021-09-02T07:25:40Z
dc.date.available2021-09-02T07:25:40Z
dc.date.issued2008
dc.identifier.citationEddleston, M., Juszczak, E., Buckley, N. A., Senarathna, L., Mohamed, F., Dissanayake, W., ... & Ox-Col Poisoning Study collaborators. (2008). Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial. The Lancet, 371(9612), 579-587.en_US
dc.identifier.urihttp://archive.cmb.ac.lk:8080/xmlui/handle/70130/5860-
dc.description.abstractThe case-fatality for intentional self-poisoning in the rural developing world is 10-50-fold higher than that in industrialised countries, mostly because of the use of highly toxic pesticides and plants. We therefore aimed to assess whether routine treatment with multiple-dose activated charcoal, to interrupt enterovascular or enterohepatic circulations, offers benefit compared with no charcoal in such an environment. We did an open-label, parallel group, randomised, controlled trial of six 50 g doses of activated charcoal at 4-h intervals versus no charcoal versus one 50 g dose of activated charcoal in three Sri Lankan hospitals. 4632 patients were randomised to receive no charcoal (n=1554), one dose of charcoal (n=1545), or six doses of charcoal (n=1533); outcomes were available for 4629 patients. 2338 (51%) individuals had ingested pesticides, whereas 1647 (36%) had ingested yellow oleander (Thevetia peruviana) seeds. Mortality was the primary outcome measure. Analysis was by intention to treat. The trial is registered with controlled-trials.com as ISRCTN02920054.Mortality did not differ between the groups. 97 (6.3%) of 1531 participants in the multipledose group died, compared with 105 (6.8%) of 1554 in the no charcoal group (adjusted odds ratio 0.96, 95% CI 0.70-1.33). No differences were noted for patients who took particular poisons, were severely ill on admission, or who presented early. We cannot recommend the routine use of multiple-dose activated charcoal in rural Asia Pacific; although further studies of early charcoal administration might be useful, effective affordable treatments are urgently needed.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.titleMultiple-dose activated charcoal in acute self-poisoning: a randomised controlled trialen_US
dc.typeArticleen_US
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