Please use this identifier to cite or link to this item:
http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5800
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Amarasekara, Sachini | - |
dc.contributor.author | Kim, Sumi | - |
dc.contributor.author | Rho, Jaerang | - |
dc.date.accessioned | 2021-08-25T05:38:12Z | - |
dc.date.available | 2021-08-25T05:38:12Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Amarasekara, D.S.; Kim, S.; Rho, J. Regulation of Osteoblast Differentiation by Cytokine Networks. Int. J. Mol. Sci. 2021, 22, 2851. https://doi.org/10.3390/ijms22062851 | en_US |
dc.identifier.uri | https://doi.org/10.3390/ijms22062851 | - |
dc.identifier.uri | http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5800 | - |
dc.description.abstract | Osteoblasts, which are bone-forming cells, play pivotal roles in bone modeling and remodeling. Osteoblast differentiation, also known as osteoblastogenesis, is orchestrated by transcription factors, such as runt-related transcription factor 1/2, osterix, activating transcription factor 4, special AT-rich sequence-binding protein 2 and activator protein-1. Osteoblastogenesis is regulated by a network of cytokines under physiological and pathophysiological conditions. Osteoblastogenic cytokines, such as interleukin-10 (IL-10), IL-11, IL-18, interferon- (IFN- ), cardiotrophin-1 and oncostatin M, promote osteoblastogenesis, whereas anti-osteoblastogenic cytokines, such as tumor necrosis factor- (TNF- ), TNF- , IL-1 , IL-4, IL-7, IL-12, IL-13, IL-23, IFN- , IFN- , leukemia inhibitory factor, cardiotrophin-like cytokine, and ciliary neurotrophic factor, downregulate osteoblastogenesis. Although there are gaps in the body of knowledge regarding the interplay of cytokine networks in osteoblastogenesis, cytokines appear to be potential therapeutic targets in bonerelated diseases. Thus, in this study, we review and discuss our osteoblast, osteoblast differentiation, osteoblastogenesis, cytokines, signaling pathway of cytokine networks in osteoblastogenesis. | en_US |
dc.language.iso | en | en_US |
dc.subject | osteoblast; osteoblast differentiation; osteoblastogenesis; cytokine; signaling pathway | en_US |
dc.title | Regulation of Osteoblast Differentiation by Cytokine Networks | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Zoology |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
ijms-22-02851.pdf | 1.1 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.