Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5770
Title: Hyperhaemolysis syndrome in haemoglobin E / beta thalassaemia responding to cyclophosphamide therapy
Authors: Senanayake, M. P.
Kuruppu, K. K. S.
Sumanasena, S. P.
Lamabadusuriya, S. P.
Keywords: Hyperhaemolysis syndrome
Thalassaemia
cyclophosphamide therapy
Issue Date: 2008
Publisher: Sri Lanka Medical Association
Citation: Senanayake, M. P., Kuruppu, K. K. S., Sumanasena, S. P., & Lamabadusuriya, S. P. (2012). Hyperhaemolysis syndrome in haemoglobin E/beta thalassaemia responding to cyclophosphamide therapy.
Abstract: Hyperhaemolysis syndrome (HS) is a rare condition where blood transfusions are followed by destruction of both donor and recipient red cells, in the absence of significant detectable red cell antibodies. This phenomenon is reported only in a few children and is extremely rare in thalassaemia syndromes. We report a case of HS in a child with low G6PD enzyme levels and Hb E beta thalassaemia, in whom intravenous immunoglobulin (IVIG), oral methylprednisolone and splenectomy failed but cyclophosphamide therapy resulted in a successful outcome.
URI: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5770
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