Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5504
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dc.contributor.authorThushara, Nadini-
dc.contributor.authorDarshani, Taniya-
dc.contributor.authorSamarakoon, Sameera R.-
dc.contributor.authorPerera, Inoka C.-
dc.contributor.authorFronczek, Frank R.-
dc.contributor.authorSameera, Sameera-
dc.contributor.authorPerera, Theshini-
dc.date.accessioned2021-07-07T03:31:32Z-
dc.date.available2021-07-07T03:31:32Z-
dc.date.issued2021-
dc.identifier.urihttp://archive.cmb.ac.lk:8080/xmlui/handle/70130/5504-
dc.description.abstractThree new Pt complexes, [PtCl2(N(SO2(2-nap))dpa)], [PtCl2(N(SO2(1-nap))dpa)] and [PtCl2(N(SO2pip)dpa)], containing a rare 8-membered ring were synthesized in good yield and high purity by utilizing the ligands N(SO2(2-nap))dpa, N(SO2(1-nap))dpa and N(SO2pip)dpa, which contain a dipicolylamine moiety. Structural studies of all three complexes confirmed that the ligands are bound in a bidentate mode via Pt–N(pyridyl) bonds forming a rare 8-membered ring. The intense fluorescence displayed by the ligands is quenched upon coordination to Pt. According to time dependent density functional theory (TDDFT) calculations, the key excitations of N(SO2(2-nap))dpa and [PtCl2(N(SO2(1-nap))dpa)] involve the 2-nap-ligand-centered π → π* excitations. While all six compounds have shown antiproliferative activity against human breast cancer cells (MCF-7), the N(SO2pip)dpa and N(SO2(2-nap))dpa ligands and [PtCl2((NSO2pip)dpa)] complex have shown significantly high cytotoxicity, directing them to be further investigated as potential anti-cancer drug leads.en_US
dc.language.isoenen_US
dc.titleSynthesis, characterization and biological evaluation of dipicolylamine sulfonamide derivatized platinum complexes as potential anticancer agentsen_US
dc.typeArticleen_US
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