Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5436
Title: Synthesis, Characterization, and Biological Studies of a Piperidinyl Appended Dipicolylamine Ligand and Its Rhenium Tricarbonyl Complex as Potential Therapeutic Agents for Human Breast Cancer
Authors: Subasinghe, Amali
Perera, Inoka C.
Pakhomova, Svetlana
Perera, Theshini
Issue Date: 2016
Citation: Subasinghe, Amali & Perera, Inoka C & Pakhomova, Svetlana & Perera, Theshini. (2016). Synthesis, Characterization, and Biological Studies of a Piperidinyl Appended Dipicolylamine Ligand and Its Rhenium Tricarbonyl Complex as Potential Therapeutic Agents for Human Breast Cancer. Bioinorganic Chemistry and Applications. 2016. 1-10. 10.1155/2016/2675937.
Abstract: A novel ligand bearing a central piperidinyl sulfonamide group, N(SO2pip)dpa, and its corresponding Re tricarbonyl complex, [Re(CO)3(N(SO2pip)dpa)]+, have been synthesized in good yield. The methylene CH2 signal seen as a singlet (4.54 ppm) in a 1H NMRspectrumof the ligand inDMSO-๐‘‘6 appears as two doublets (5.39, 5.01 ppm) in a spectrumof the [Re(CO)3(N(SO2pip)dpa)]+ complex and confirms the presence ofmagnetically nonequivalent protons upon coordination to Re. Structural results revealed that theReโ€“N bond lengths fall within the normal range establishing coordination of ligand tometal.The presence of intraligand๐œ‹ โ†’ ๐œ‹โˆ— and๐‘› โ†’ ๐œ‹โˆ— transitions is indicated by the absorption peaks around 200โ€“250 nm in UV-visible spectra. Absorption peaks in UVvisible spectra around 300 nmfor metal complexes were identified asMLCT transitions.The Sโ€“N stretch observed as a strong peak at 923 cmโˆ’1 forN(SO2pip)dpa appeared at a shorter frequency, at 830 cmโˆ’1 in an FTIR spectrum of the [Re(CO)3(N(SO2pip)dpa)]+. The intense fluorescence displayed by the N(SO2pip)dpa ligand has quenched upon coordination to Re. Relatively low IC50 values given by human breast cancer cells, MCF-7, (N(SO2pip)dpa = 139 ๐œ‡M, [Re(CO)3(N(SO2pip)dpa)]+ = 360๐œ‡M) indicate that N(SO2pip)dpa and [Re(CO)3(N(SO2pip)dpa)]+ are promising novel compounds that can be further investigated on their usage as potential anticancer agents.
URI: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5436
Appears in Collections:Department of Zoology

Files in This Item:
File Description SizeFormat 
Subasinghe et al_2016_Bioinorganic Chemistry and Applications.pdf4 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.