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Title: | Proportion of Helicobacter pylori Among Dyspeptic Patients Detected by Molecular Methods in a Teaching Hospital in Sri Lank |
Authors: | Ubhayawardana, D. L Weerasekera, M. M Weerasekera, D. D Gunasekera, T. D Fernando, S. S |
Keywords: | Helicobacter Dyspepsia Risk Factors PCR |
Issue Date: | 2015 |
Citation: | Ubhayawardana, D. L., Weerasekera, M. M., Weerasekera, D. D., Gunasekera, T. D., & Fernando, S. S. (2015). Proportion of Helicobacter pylori among dyspeptic patients detected by molecular methods in a teaching hospital in Sri Lanka. Int J Enteric Pathog, 3(4), 1-3. |
Abstract: | Background: Infection with Helicobacter pylori is considered as a major cause of chronic gastritis, peptic ulcer disease and gastric cancer. More than half of the world’s population is infected with H. pylori. In Sri Lanka various groups have reported a prevalence ranging from 3% to 70% over the last decade. Objectives: The aim of this study was to determine the current proportion of H. pylori and risk factors for H. pylori infections. Patients and Methods: The study was a cross sectional, descriptive study in which 100 dyspeptic patients who were required to undergo endoscopy examination were included. The study was carried out at a Teaching Hospital in Sri Lanka. In-house urease test and PCR amplification of the glmM gene of H. pylori was performed to diagnose H. pylori infection. A questionnaire was filled to collect sociodemographic data from the dyspeptic patients. Results: Eighteen dyspeptic patients were positive for H. pylori by both in-house CLO (Campylobacter-like organism test) test and polymerase chain reaction (PCR). Ten of cases were male (18%) while eight were female (17%). There was no association between the demographic factors and risk of H. pylori infection. Conclusions: The proportion of H. pylori infections was found to be 18% in the study population. There was no significant association with H. pylori and the studied demographic factors. |
URI: | http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5299 |
Appears in Collections: | Department of Basic Sciences & Social Sciences |
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