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dc.contributor.authorFernando, I.P. Shanura-
dc.contributor.authorJayawardena, Thilina U.-
dc.contributor.authorKim, Hyun-Soo-
dc.contributor.authorLee, Won Woo-
dc.contributor.authorVaas, A.P.J.P.-
dc.contributor.authorDe Silva, H.I.C.-
dc.contributor.authorAbayaweera, G.S.-
dc.contributor.authorNanayakkara, C.M.-
dc.contributor.authorAbeytunga, D.T.U.-
dc.contributor.authorLee, Dae-Sung-
dc.contributor.authorJeon, You-Jin-
dc.date.accessioned2021-06-05T10:26:45Z-
dc.date.available2021-06-05T10:26:45Z-
dc.date.issued2019-
dc.identifier.citationI.P. Shanura Fernando, Thilina U. Jayawardena, Hyun-Soo Kim, Won Woo Lee, A.P.J.P. Vaas, H.I.C. De Silva, G.S. Abayaweera, C.M. Nanayakkara, D.T.U. Abeytunga, Dae-Sung Lee, You-Jin Jeon (2019). Beijing urban particulate matter-induced injury and inflammation in human lung epithelial cells and the protective effects of fucosterol from Sargassum binderi(Sonder ex J. Agardh), Environmental Research172 pg150–158en_US
dc.identifier.urihttps://doi.org/10.1016/j.envres.2019.02.016-
dc.identifier.urihttp://archive.cmb.ac.lk:8080/xmlui/handle/70130/5259-
dc.description.abstractParticulate matter (PM) air pollution has gradually become a widespread problem in East Asia. PM may cause unfamiliar inflammatory responses, oxidative stress, and pulmonary tissue damage, and a comprehensive un- derstanding of the underlying mechanisms is required in order to develop effective anti-inflammatory agents. In this study, fine dust collected from Beijing, China (CPM) (size < PM13 with majority < PM2.5) was evaluated for its oxidative stress- and inflammation-inducing effects, which cause cell damage, in A459 human lung epi- thelial cells. Oxidative stress was marked by an increase in intracellular ROS levels and the production of an- tioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and heme oxygenase-1 (HO-1). Upon induction of oxidative stress, a marked increase was observed in the expression of key inflammatory mediators such as COX-2 and PGE2 and the pro-inflammatory cytokines TNF-α and IL-6 via NF-kB and MAPK pathways. Cellular damage was marked by a reduction in viability, increased lactate dehydrogenase (LDH) release, for- mation of apoptotic and necrotic bodies, accumulation of sub-G1 phase cells, and DNA damage. Apoptosis was found to be mediated via the activation of caspases through the mitochondria-mediated pathway. Fucosterol, purified from the brown alga Sargassum binderi (Sonder ex J. Agardh) by bio-assay-guided fractionation and purification, exhibited potential therapeutic effects against CPM-induced detrimental effects. Further studies could focus on developing fucosterol, in forms such as steroidal inhalers, against PM-induced pulmonary tissue inflammation.en_US
dc.language.isoenen_US
dc.subjectFine dust, Airway inflammation, A549, Sargassum binderi, Fucosterolen_US
dc.titleBeijing urban particulate matter-induced injury and inflammation in human lung epithelial cells and the protective effects of fucosterol from Sargassum binderi (Sonder ex J. Agardh)en_US
dc.typeArticleen_US
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