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DC Field | Value | Language |
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dc.contributor.author | Fernando, I.P. Shanura | - |
dc.contributor.author | Jayawardena, Thilina U. | - |
dc.contributor.author | Kim, Hyun-Soo | - |
dc.contributor.author | Lee, Won Woo | - |
dc.contributor.author | Vaas, A.P.J.P. | - |
dc.contributor.author | De Silva, H.I.C. | - |
dc.contributor.author | Abayaweera, G.S. | - |
dc.contributor.author | Nanayakkara, C.M. | - |
dc.contributor.author | Abeytunga, D.T.U. | - |
dc.contributor.author | Lee, Dae-Sung | - |
dc.contributor.author | Jeon, You-Jin | - |
dc.date.accessioned | 2021-06-05T10:26:45Z | - |
dc.date.available | 2021-06-05T10:26:45Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | I.P. Shanura Fernando, Thilina U. Jayawardena, Hyun-Soo Kim, Won Woo Lee, A.P.J.P. Vaas, H.I.C. De Silva, G.S. Abayaweera, C.M. Nanayakkara, D.T.U. Abeytunga, Dae-Sung Lee, You-Jin Jeon (2019). Beijing urban particulate matter-induced injury and inflammation in human lung epithelial cells and the protective effects of fucosterol from Sargassum binderi(Sonder ex J. Agardh), Environmental Research172 pg150–158 | en_US |
dc.identifier.uri | https://doi.org/10.1016/j.envres.2019.02.016 | - |
dc.identifier.uri | http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5259 | - |
dc.description.abstract | Particulate matter (PM) air pollution has gradually become a widespread problem in East Asia. PM may cause unfamiliar inflammatory responses, oxidative stress, and pulmonary tissue damage, and a comprehensive un- derstanding of the underlying mechanisms is required in order to develop effective anti-inflammatory agents. In this study, fine dust collected from Beijing, China (CPM) (size < PM13 with majority < PM2.5) was evaluated for its oxidative stress- and inflammation-inducing effects, which cause cell damage, in A459 human lung epi- thelial cells. Oxidative stress was marked by an increase in intracellular ROS levels and the production of an- tioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and heme oxygenase-1 (HO-1). Upon induction of oxidative stress, a marked increase was observed in the expression of key inflammatory mediators such as COX-2 and PGE2 and the pro-inflammatory cytokines TNF-α and IL-6 via NF-kB and MAPK pathways. Cellular damage was marked by a reduction in viability, increased lactate dehydrogenase (LDH) release, for- mation of apoptotic and necrotic bodies, accumulation of sub-G1 phase cells, and DNA damage. Apoptosis was found to be mediated via the activation of caspases through the mitochondria-mediated pathway. Fucosterol, purified from the brown alga Sargassum binderi (Sonder ex J. Agardh) by bio-assay-guided fractionation and purification, exhibited potential therapeutic effects against CPM-induced detrimental effects. Further studies could focus on developing fucosterol, in forms such as steroidal inhalers, against PM-induced pulmonary tissue inflammation. | en_US |
dc.language.iso | en | en_US |
dc.subject | Fine dust, Airway inflammation, A549, Sargassum binderi, Fucosterol | en_US |
dc.title | Beijing urban particulate matter-induced injury and inflammation in human lung epithelial cells and the protective effects of fucosterol from Sargassum binderi (Sonder ex J. Agardh) | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Plant Sciences |
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File | Description | Size | Format | |
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FernandoIPSEnvironmentalResearch1722019150158.pdf | 2.38 MB | Adobe PDF | View/Open |
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