Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5256
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dc.contributor.authorJayawardena, Thilina U.-
dc.contributor.authorSanjeewa, K. K. Asanka-
dc.contributor.authorNagahawatta, D. P.-
dc.contributor.authorLee, Hyo-Geun-
dc.contributor.authorLu, Yu-An-
dc.contributor.authorVaas, A. P. J. P.-
dc.contributor.authorAbeytunga, D. T. U.-
dc.contributor.authorNanayakkara, C.M.-
dc.contributor.authorLee, Dae-Sung-
dc.contributor.authorJeon, You-Jin-
dc.date.accessioned2021-06-05T10:25:36Z-
dc.date.available2021-06-05T10:25:36Z-
dc.date.issued2020-
dc.identifier.citationThilina U. Jayawardena, K. K. Asanka Sanjeewa , D. P. Nagahawatta, Hyo-Geun Lee, Yu-An Lu, A. P. J. P. Vaas, D. T. U. Abeytunga, C. M. Nanayakkara, Dae-Sung Lee, and You-Jin Jeon (2020). Anti-Inflammatory Effects of Sulfated Polysaccharide from Sargassum swartziiin Macrophages via Blocking TLR/NF-Kb Signal Transduction, Marine Drugs 2020 18, 601, 1-20en_US
dc.identifier.urihttps://doi.org/10.3390/md18120601-
dc.identifier.urihttp://archive.cmb.ac.lk:8080/xmlui/handle/70130/5256-
dc.description.abstractThis study involves enzymatic extraction of fucoidan from Sargassum swartzii and further purification via ion-exchange chromatography. The chemical and molecular characteristics of isolated fucoidan is evaluated concerning its anti-inflammatory potential in RAW 264.7 macrophages under LPS induced conditions. Structural properties of fucoidan were assessed via FTIR and NMR spectroscopy. NO production stimulated by LPS was significantly declined by fucoidan. This was witnessed to be achieved via fucoidan acting on mediators such as iNOS and COX-2 including pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), with dose dependent down-regulation. Further, the effect is exhibited by the suppression of TLR mediated MyD88, IKK complex, ultimately hindering NF-κB and MAPK activation, proposing its therapeutic applications in inflammation related disorders. The research findings provide an insight in relation to the sustainable utilization of fucoidan from marine brown algae S. swartzii as a potent anti-inflammatory agent in the nutritional, pharmaceutical, and cosmeceutical sectors.en_US
dc.language.isoenen_US
dc.publisherMarine Drugsen_US
dc.subjectSargassum swartzii; TLR/MyD88; NF-κB; MAPK; fucoidanen_US
dc.titleAnti-Inflammatory Effects of Sulfated Polysaccharide from Sargassum swartzii in Macrophages via Blocking TLR/NF-Kb Signal Transductionen_US
dc.typeArticleen_US
Appears in Collections:Department of Plant Sciences



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