Please use this identifier to cite or link to this item: http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5240
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dc.contributor.authorRajapaksa, G.K.-
dc.contributor.authorDe Silva, V.-
dc.contributor.authorGoonathilake, S.-
dc.contributor.authorAthukorala, I.-
dc.contributor.authorWijayarathna, L.S.-
dc.contributor.authorUdagama-Randeniya, P.V.-
dc.date.accessioned2021-06-05T10:16:47Z-
dc.date.available2021-06-05T10:16:47Z-
dc.date.issued2009-
dc.identifier.citation2en_US
dc.identifier.otherhttps://doi.org/10.1016/S0973-3698(10)60154-9-
dc.identifier.urihttp://archive.cmb.ac.lk:8080/xmlui/handle/70130/5240-
dc.description.abstractObjective: To study the immunological profile, disease characteristics and socioeconomic status of a population of patients with rheumatoid arthritis (RA) in Sri Lanka. Methods: A case-control study was undertaken to characterize the immunoglobulin profiles of 105RA and, age and gender matched osteoarthritis (OA) patients (n=30) from the National Hospital, Sri Lanka.Healthy, non-arthritic individuals (n=30) served as controls.Sera were assayed for immunoglobulins [IgG, IgM, IgE and IgA isotypes] by establishing sandwich type ELISA.IgM, IgG and IgA rheumatoid factors (RFs) of 162RA patients were assayed by indirect ELISA. Disease characteristics and socioeconomic factors were accrued via an interviewer-administered questionnaire. Results: Higher IgG, IgM, IgE, IgA and lower IgG1, IgG2 levels were observed in RA sera compared with controls (P<0.05).Novel correlations between disease characteristics and immunoglobulins, as well as group-specific correlation matrices of immunoglobulins and RFs (P<0.05) of seropositive and seronegative patients, were found.Higher IgM-RF and IgA-RF levels in seropositives and IgG-RF in seronegatives were evident compared with controls (P<0.05).Immunoglobulin and RF profiles did not reflect gender disparity of RA (P>0.05).Proportions of seropositives with nodules and erosions were significantly higher than seronegatives (P<0.05).While IgM-RF and erosions positively correlated in the seropositives (P<0.05), the seronegatives showed an inverse correlation between IgG-RF and erosions (P<0.01).Familial clustering imposed a relative risk of 4.7 for developing seropositive RA. Conclusions: This model study provides baseline information on pathogenetic aspects of RA in Sri Lanka, which may have implications for further research on management of the disease.en_US
dc.description.sponsorshipUniversity of Colombo, Sri Lankaen_US
dc.language.isoenen_US
dc.subjectDisease profileen_US
dc.subjectsocioeconomic factorsen_US
dc.subjectseropositiveen_US
dc.subjectELISAen_US
dc.subjecterosionsen_US
dc.subjectimmunoglobulin profilesen_US
dc.subjectnodulesen_US
dc.subjectrheumatoid factorsen_US
dc.subjectrisk factorsen_US
dc.subjectseronegativeen_US
dc.titleA study of immunological profile, disease characteristics and socioeconomic status of a population of rheumatoid arthritis patients in Sri Lankaen_US
dc.typeArticleen_US
Appears in Collections:Department of Zoology

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