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DC Field | Value | Language |
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dc.contributor.author | Fonseka, Sanjeewani | - |
dc.contributor.author | Wijeyaratne, Chandrika N | - |
dc.contributor.author | Gawarammana, Indika B | - |
dc.contributor.author | Kalupahana, Nishan | - |
dc.contributor.author | Rosairo, Shanthini | - |
dc.contributor.author | Ratnatunga, Neelakanthi | - |
dc.contributor.author | Kumarasiri, Ranjith | - |
dc.date.accessioned | 2021-02-22T17:41:01Z | - |
dc.date.available | 2021-02-22T17:41:01Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Fonseka S, Wijeyaratne CN, Gawarammana IB, Kalupahana NS, Rosairo S, Ratnatunga N, Kumarasiri R. Effectiveness of Low-dose Ethinylestradiol/Cyproterone Acetate and Ethinylestradiol/Desogestrel with and without Metformin on Hirsutism in Polycystic Ovary Syndrome: A Randomized, Double-blind, Triple-dummy Study. J Clin Aesthet Dermatol. 2020 Jul;13(7):18-23. Epub 2020 Jul 1. | en_US |
dc.identifier.uri | http://archive.cmb.ac.lk:8080/xmlui/handle/70130/5074 | - |
dc.description.abstract | BACKGROUND: The effectiveness of different combined oral contraceptive pills and metformin in reducing hirsutism in patients with polycystic ovary syndrome (PCOS) remains unclear. OBJECTIVE: We sought to determine the effects of ethinylestradiol (35μg)/cyproterone acetate (2mg) (EE/CPA) and ethinylestradiol (20μg)/desogestrel (0.15mg) (EE/DES), alone or with metformin, on hirsutism in PCOS. METHODS: A randomized, double-blind, triple-dummy study was conducted on women with PCOS and hirsutism (N=107) who received one of four drug combinations (Arm A: EE/CPA; Arm B: EE/DES; Arm C: EE/CPA plus metformin; or Arm D: EE/DES plus metformin). Hirsutism was assessed at baseline, six months, and 12 months by using five outcomes variables. RESULTS: No outcomes variable showed a significant difference between the four arms at 12 months. There was a significant reduction in both hair density and modified Ferriman-Gallwey score (mFGS) in Arm A, mFGS in Arm B, hair density in Arm C, and diameter of sideburn hair in Arm D, respectively. Separately, there was a significant increase noted in the hair growth rate of chin and an improvement in patients' perceptions of hirsutism in all four study arms. CONCLUSION: EE/CPA and EE/DES were equally effective in improving hirsutism in PCOS, with no added benefit from low-dose metformin. Sri Lanka Clinical Trials Registry (http://www.slctr.lk) registration no. SLCTR/2015/007. Keywords: Ferriman-Gallwey score; Hirsutism; cyproterone acetate; desogestrel; hair density; hair diameter; hair growth rate; metformin; polycystic ovary syndrome. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Edgemont, PA : Matrix Medical Communications | en_US |
dc.subject | Ferriman-Gallwey score | en_US |
dc.subject | Hirsutism | en_US |
dc.subject | cyproterone acetate | en_US |
dc.subject | desogestrel | en_US |
dc.subject | hair density | en_US |
dc.subject | hair diameter | en_US |
dc.subject | hair growth rate | en_US |
dc.subject | metformin | en_US |
dc.subject | polycystic ovary syndrome | en_US |
dc.title | Effectiveness of Low-dose Ethinylestradiol/Cyproterone Acetate and Ethinylestradiol/Desogestrel with and without Metformin on Hirsutism in Polycystic Ovary Syndrome | en_US |
dc.title.alternative | A Randomized, Double-blind, Triple-dummy Study. | en_US |
dc.type | Article | en_US |
Appears in Collections: | Department of Obstetrics & Gynaecology |
Files in This Item:
File | Description | Size | Format | |
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jcad_13_7_18.pdf | 328.3 kB | Adobe PDF | View/Open |
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