Carcinoma of prostate- retrospective analysis of 103 patients during 2000-2002

Abstract

This study is a retrospective analysis of cases of carcinoma of rostate.)ne objective of study is to analyze the epidenuo ogy, presentation, prognostic variables and the treatment offered in one ~olOgy umt m NatIOnal Cancer InstItute Maharagam. Further to get an insight into possible fu_rther development in improving quality of care in futurePatient population was identified through search into patients clinical records maintained at the medical record room National Cancer Institute Maharagama.Median number of cases per year was 34; average age was 71.4 years; 67 percentage cases were from Western province; Commonest presenting symptom was dysurea and frequency; No statistically significant difference of incidence of prostate cancer in different ethnic groups in Sri Lanka (P=0.01) 48 percent cases had associated other comorbidities average presenting PSA value was 97 4ng/ml; majority of patients ( 56 percent) had a Gleason score between 7-10, 36 percent cases as localized disease and 34 percent cases as metastatic disease , and metastatic status was not assessed in 30 percent of cases out of these 77.4 percent had PSA more than 20ng/ml. No correlation between age and PSA (p=o.5), age and Gleason score (p=O.65) or PSA and Gleason score(p+0.23). In contrast there was signicant relationship between increasing presenting PSA and presence of metastases ( p=<O,OO1) and Gleason score and presence of metastases ( p.O.OO1). Radical treatment was offered for 38 percent cases, 56 percent cases were offered palliative treatment. Radical radiotheraphy was the mode of radical theraphy in 92.5 percent of cases, 96.5 percent of palliative treatment was orchiectomy, Non surgical and rogen deprivation therapy was uses in 5 percent of radically treated cases and 10 percent of palliatively treated cases only. Sub group analysis of radically treated cases showed no statistically significant correlation between increasing PSA and recurrence tate (p=0.34) or increase in Gleason score and recurrence rate (p=0.81)